| 文獻 | 2026 | 神經 | Ganoderma microsporum-derived fungal immunomodulatory protein (GMI) promotes functional recovery after spinal cord injury by modulating anti-inflammation and enhancing regeneration Tu et al.．Experimental Neurology 脊髓損傷．抗發炎．神經再生．免疫調節 | 原文GMIBIO |
| 文獻 | 2026 | 癌症 | Ganoderma microsporum Immunomodulatory Protein (GMI) Enhances Phagocytosis by Suppressing STAT3/CD47 Signaling in EGFR-Mutant NSCLC Resistant to Gefitinib and Osimertinib Hsieh et al.．Journal of Cancer 癌症．肺癌．抗藥性．免疫調節 | 原文GMIBIO |
| 文獻 | 2026 | 癌症 | Ganoderma Microsporum immunomodulatory protein suppresses osteosarcoma growth through redox imbalance and ER stress-driven apoptosis Sun et al.．Bioorganic Chemistry 癌症．骨肉瘤 | 原文GMIBIO |
| 專利 | 2026 | 感染與抗病毒 | GMI 冠狀病毒感染預防 TW TWI927137B 冠狀病毒疾病．抗病毒 | 原文GMIBIO |
| 專利 | 2026 | 平台技術與安全性 | GMI 外泌體組成物 TW TWI921862B 外泌體 | 原文GMIBIO |
| 文獻 | 2025 | 癌症 | rFIP-GMI Suppresses IGF-1-Induced Invasion and Migration in Breast Cancer Cells via PI3K/Akt/β-Catenin Inhibition Liao et al.．Drug Development Research 癌症．乳癌．腫瘤轉移 | 原文GMIBIO |
| 文獻 | 2025 | 癌症 | GMI, a Fungal Immunomodulatory Protein From Ganoderma microsporum, Induces Different Cytotoxicity in Parental and Osimertinib-Resistant EGFR-Mutated Lung Cancer Cells via Apoptotic and Autophagic Cell Death Kang et al.．Basic & Clinical Pharmacology & Toxicology 癌症．肺癌．抗藥性 | 原文GMIBIO |
| 文獻 | 2025 | 癌症 | Suppression of tumor growth by GMI, an edible fungal immunomodulatory protein, is associated with targeting GSK3β‑mediated proteasomal degradation of PD‑L1 Hua et al.．International Journal of Molecular Medicine 癌症．肺癌．免疫調節 | 原文GMIBIO |
| 文獻 | 2025 | 感染與抗病毒 | Broad-spectrum antiviral activity of Ganoderma microsporum immunomodulatory protein: Targeting glycoprotein gB to inhibit EBV and HSV-1 infections via viral fusion blockage Vo et al.．International Journal of Biological Macromolecules 抗病毒 | 原文GMIBIO |
| 專利 | 2025 | 組織修復 | GMI 促進幹細胞增殖 TW TWI864278B、US US12180506B2、JP JP7785496B2 幹細胞增殖 | 原文GMIBIO |
| 文獻 | 2024 | 癌症 | Integrin αV Inhibition by GMI, a Ganoderma Microsporum Immunomodulatory Protein, Abolish Stemness and Migration in EGFR-Mutated Lung Cancer Cells Resistant to Osimertinib Kang et al.．Environmental Toxicology 癌症．肺癌．抗藥性．癌幹細胞．腫瘤轉移 | 原文GMIBIO |
| 文獻 | 2024 | 肌肉與代謝 | Regimen on Dnaja3 haploinsufficiency mediated sarcopenic obesity with imbalanced mitochondrial homeostasis and lipid metabolism Fann et al.．Journal of Cachexia, Sarcopenia and Muscle 肌母細胞分化 | 原文GMIBIO |
| 文獻 | 2024 | 組織修復 | Ganoderma Microsporum Immunomodulatory Protein Alleviates Inflammaging and Oxidative Stress in Diabetes-Associated Periodontitis via Nrf2 Signaling Activation: An In Vitro Study Su et al.．Antioxidants 牙周炎．抗發炎．抗氧化 | 原文GMIBIO |
| 文獻 | 2024 | 癌症 | Ganoderma microsporum immunomodulatory protein combined with KRASG12C inhibitor impedes intracellular AKT/ERK network to suppress lung cancer cells with KRAS mutation Hua et al.．International Journal of Biological Macromolecules 癌症．肺癌 | 原文GMIBIO |
| 文獻 | 2024 | 人體臨床研究 | Effects of Reishimmune-S, a Fungal Immunomodulatory Peptide Supplement, on the Quality of Life and Circulating Natural Killer Cell Profiles of Patients With Early Breast Cancer Receiving Adjuvant Endocrine Therapy Su et al.．Integrative Cancer Therapies 癌症．乳癌．免疫調節 | 原文GMIBIO |
| 專利 | 2024 | 環境壓力與抗氧化 | GMI 與 PM2.5 損傷防護 TW TWI783135B、US US11077168B2、CN CN110354251B 細懸浮微粒．免疫調節．抗氧化 | 原文GMIBIO |
| 專利 | 2024 | 組織修復 | GMI 慢性傷口癒合 TW TWI773927B、US US11141458B2、CN CN112316108B 傷口癒合 | 原文GMIBIO |
| 專利 | 2024 | 感染與抗病毒 | GMI 冠狀病毒疾病治療 TW TWI859701B、US US12122809B2 冠狀病毒疾病．抗病毒 | 原文GMIBIO |
| 文獻 | 2023 | 癌症 | GMI, a Ganoderma microsporum protein, abolishes focal adhesion network to reduce cell migration and metastasis of lung cancer Lo et al.．Life Sciences 癌症．肺癌．腫瘤轉移 | 原文GMIBIO |
| 文獻 | 2023 | 癌症 | Ganoderma microsporum immunomodulatory protein as an extracellular epidermal growth factor receptor (EGFR) degrader for suppressing EGFR-positive lung cancer cells Hua et al.．Cancer Letters 癌症．肺癌 | 原文GMIBIO |
| 文獻 | 2023 | 感染與抗病毒 | GMI, a fungal immunomodulatory protein, ameliorates SARS-CoV-2 envelope protein-induced inflammation in macrophages via inhibition of MAPK pathway Lin et al.．International Journal of Biological Macromolecules 冠狀病毒疾病．抗發炎．免疫調節 | 原文GMIBIO |
| 文獻 | 2022 | 感染與抗病毒 | Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusion Ho et al.．Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 冠狀病毒疾病．抗病毒 | 原文GMIBIO |
| 文獻 | 2022 | 癌症 | GMI, Ganoderma microsporum protein, suppresses cell mobility and increases temozolomide sensitivity through induction of Slug degradation in glioblastoma multiforme cells Tseng et al.．International Journal of Biological Macromolecules 癌症．腦癌．抗藥性．腫瘤轉移 | 原文GMIBIO |
| 文獻 | 2022 | 感染與抗病毒 | GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virus Yeh et al.．Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 冠狀病毒疾病．抗病毒 | 原文GMIBIO |
| 文獻 | 2022 | 平台技術與安全性 | Safety assessment of the fungal immunomodulatory protein from Ganoderma microsporum (GMI) derived from engineered Pichia pastoris: Genetic toxicology, a 13-week oral gavage toxicity study, and an embryo-fetal developmental toxicity study in Sprague-Dawley rats Fu et al.．Toxicology Reports 安全性 | 原文GMIBIO |
| 文獻 | 2022 | 神經 | Immunomodulatory protein from ganoderma microsporum protects against oxidative damages and cognitive impairments after traumatic brain injury Chao et al.．Molecular and Cellular Neurosciences 創傷性腦損傷．抗氧化．神經再生 | 原文GMIBIO |
| 文獻 | 2022 | 人體臨床研究 | Efficacy of GMI, a fungal immunomodulatory protein, for head and neck cancer patients with chemotherapy-related oral mucositis: An open-labeled prospective single-arm study Lu et al.．Medicine 口腔黏膜炎．頭頸癌 | 原文GMIBIO |
| 文獻 | 2021 | 免疫調節與抗發炎 | GMI, an Immunomodulatory Peptide from Ganoderma microsporum, Restrains Periprosthetic Joint Infections via Modulating the Functions of Myeloid-Derived Suppressor Cells and Effector T Cells Peng et al.．International Journal of Molecular Sciences 免疫調節 | 原文GMIBIO |
| 文獻 | 2021 | 癌症 | Combination treatment of Src inhibitor Saracatinib with GMI, a Ganoderma microsporum immunomodulatory protein, induce synthetic lethality via autophagy and apoptosis in lung cancer cells Chiu et al.．Journal of Cellular Physiology 癌症．肺癌 | 原文GMIBIO |
| 文獻 | 2021 | 癌症 | Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells Lin et al.．Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 癌症．肺癌 | 原文GMIBIO |
| 專利 | 2021 | 平台技術與安全性 | 抗 GMI 單株抗體與應用 CN CN107287166B 單株抗體 | 原文GMIBIO |
| 專利 | 2021 | 神經 | GMI 促進神經突生長 TW TWI723000B、US US9975931B2 神經再生 | 原文GMIBIO |
| 專利 | 2021 | 組織修復 | GMI 抗纖維化應用 TW TWI670066B、US US11058746B2 抗纖維化 | 原文GMIBIO |
| 文獻 | 2020 | 肌肉與代謝 | Ganoderma microsporum immunomodulatory protein, GMI, promotes C2C12 myoblast differentiation in vitro via upregulation of Tid1 and STAT3 acetylation Teo et al.．PloS One 肌母細胞分化 | 原文GMIBIO |
| 文獻 | 2020 | 癌症 | CD133 inhibition via autophagic degradation in pemetrexed-resistant lung cancer cells by GMI, a fungal immunomodulatory protein from Ganoderma microsporum Hsin et al.．British Journal of Cancer 癌症．肺癌．抗藥性 | 原文GMIBIO |
| 文獻 | 2019 | 癌症 | Inhibition of proliferation and migration of melanoma cells by ketoconazole and Ganoderma immunomodulatory proteins Lu et al.．Oncology Letters 癌症．黑色素瘤．腫瘤轉移 | 原文GMIBIO |
| 文獻 | 2019 | 環境壓力與抗氧化 | The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM2.5-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings Tseng et al.．Scientific Reports 細懸浮微粒．抗發炎．抗氧化 | 原文GMIBIO |
| 文獻 | 2019 | 癌症 | The Protective Role of GMI, an Immunomodulatory Protein From Ganoderma microsporum, on 5-Fluorouracil-Induced Oral and Intestinal Mucositis Li et al.．Integrative Cancer Therapies 口腔黏膜炎 | 原文GMIBIO |
| 文獻 | 2018 | 癌症 | Ganoderma immunomodulatory protein and chidamide down-regulate integrin-related signaling pathway result in migration inhibition and apoptosis induction Lu et al.．Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 癌症．黑色素瘤．腫瘤轉移 | 原文GMIBIO |
| 文獻 | 2018 | 神經 | Anti-inflammatory and Neuroprotective Effects of Fungal Immunomodulatory Protein Involving Microglial Inhibition Chen et al.．International Journal of Molecular Sciences 抗發炎．免疫調節．抗氧化．神經再生 | 原文GMIBIO |
| 文獻 | 2018 | 癌症 | GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via β-catenin suppression in lung cancer cells Hsin et al.．Environmental Toxicology 癌症．肺癌 | 原文GMIBIO |
| 文獻 | 2018 | 癌症 | Ganoderma microsporum immunomodulatory protein induces apoptosis and potentiates mitomycin C-induced apoptosis in urinary bladder urothelial carcinoma cells Huang et al.．Journal of Cellular Biochemistry 癌症．膀胱癌 | 原文GMIBIO |
| 文獻 | 2018 | 組織修復 | Inhibitory effect of GMI, an immunomodulatory protein from Ganoderma microsporum, on myofibroblast activity and proinflammatory cytokines in human fibrotic buccal mucosal fibroblasts Lee et al.．Environmental Toxicology 抗纖維化．抗發炎 | 原文GMIBIO |
| 專利 | 2018 | 癌症 | GMI 抑制癌幹細胞 US US9937226B2 癌症．癌幹細胞 | 原文GMIBIO |
| 文獻 | 2017 | 癌症 | GMI ablates cancer stemness and cisplatin resistance in oral carcinomas stem cells through IL-6/Stat3 signaling inhibition Wang et al.．Oncotarget 癌症．頭頸癌．癌幹細胞．抗藥性 | 原文GMIBIO |
| 專利 | 2017 | 癌症 | GMI 難治／復發肺癌應用 US US9827288B2 癌症．肺癌 | 原文GMIBIO |
| 文獻 | 2015 | 癌症 | Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells Chiu et al.．PloS One 癌症．肺癌．抗藥性 | 原文GMIBIO |
| 文獻 | 2015 | 癌症 | GMI, an Immunomodulatory Protein from Ganoderma microsporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells Hsin et al.．Molecular Pharmaceutics 癌症．肺癌 | 原文GMIBIO |
| 專利 | 2015 | 癌症 | GMI 乳癌應用 US US9018171B2 癌症．乳癌 | 原文GMIBIO |
| 專利 | 2015 | 癌症 | GMI 多癌別應用（US） US US9161964B2 癌症．肺癌．乳癌．肝癌．大腸直腸癌 | 原文GMIBIO |
| 專利 | 2013 | 癌症 | GMI 肺癌應用 US US8476238B2 癌症．肺癌 | 原文GMIBIO |
| 專利 | 2013 | 癌症 | GMI 多癌別應用（TW） TW TWI414307B 癌症．肺癌．頭頸癌．乳癌．膀胱癌．腦癌．肝癌．大腸直腸癌 | 原文GMIBIO |
| 文獻 | 2012 | 癌症 | Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum Hsin et al.．British Journal of Pharmacology | 原文GMIBIO |
| 文獻 | 2011 | 癌症 | GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells Hsin et al.．Autophagy 癌症．肺癌 | 原文GMIBIO |
| 文獻 | 2010 | 免疫調節與抗發炎 | GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor α-induced expression of matrix metalloproteinase 9 via NF-κB pathway in human alveolar epithelial A549 cells Lin et al.．Journal of Agricultural and Food Chemistry 抗發炎 | 原文GMIBIO |
| 文獻 | 2010 | 癌症 | A new immunomodulatory protein from <i>Ganoderma microsporum</i> inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells Lin et al.．Process Biochemistry 癌症．肺癌．腫瘤轉移 | 原文GMIBIO |
| 專利 | 2008 | 平台技術與安全性 | GMI 免疫調節蛋白序列與選殖 TW TWI299735B、US US7601808B2 | 原文GMIBIO |